Chromosomal Proteins HMGN3a and HMGN3b Regulate the Expression of Glycine Transporter 1
نویسندگان
چکیده
منابع مشابه
Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1.
HMGN proteins promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. It is not known whether they act indiscriminately as general modulators of transcription or whether they regulate specific gene expression. Here, we investigated the role of HMGN3, a recently discovered HMGN family member, in transcription in vivo. We created cell lines...
متن کاملThe chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across the Glyt1 gene.
HMGNs are nucleosome-binding proteins that alter the pattern of histone modifications and modulate the binding of linker histones to chromatin. The HMGN3 family member exists as two splice forms, HMGN3a which is full-length and HMGN3b which lacks the C-terminal RD (regulatory domain). In the present study, we have used the Glyt1 (glycine transporter 1) gene as a model system to investigate wher...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2004
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.24.9.3747-3756.2004